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"AngIV-analog dihexa rescues cognitive impairment and recovers memory in the APP/PS1 mouse via the PI3K/AKT signaling pathway."Brain sciences11.11 (2021): 1487

These MAIT cells have a semi-invariant T-cell receptor TCR (TRAV1-2TRAJ33) (TRBV20-TRBV6) and can be activated upon recognition of the riboflavin derivatives 5-OP-RU, 5-OE-RU, or RL-6,7-diMe bound to Major Histocompatibility complex class 1 related (MR1) protein, which is ubiquitously expressed on the cell surface of epithelial cells and immune cells 187

Its biochemical properties have been investigated in cellular, tissue and animal models, while human evidence for intranasal use remains insufficient for establishing clinical benefits, pharmacokinetics or long-term safety

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